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目的:比较胺碘酮和普罗帕酮分别治疗室性心律失常前后Q-Tc间期的变化及对复发的影响。方法:测定2组病人用药前后2周的Q-Tcd。结果:①胺碘酮用药后Q-Tc明显延长,但Q-Tcd反而降低(44.3±14.9)mg与(33.9±16.1)ms,(P<0.05),普罗帕酮组用药前后Q-Tc及Q-Tcd无显著变化(P均>0.05)。②碘胺酮组和普罗帕酮组的有效率分别为85.2%和82.4%(P>0.05),停药后1月内的室性心律失常复发率分别为18.5%和50%(P>0.05)普罗帕酮组复发者较未复者的Q-Tcd明显延长(48.7±15.3)ms与(39.8±12.5)ms,(P<0.01)。结论:Q-Tcd的降低可能是胺碘酮治疗室性心律失常复发率较低的重要因素。
Objective: To compare the changes of Q-Tc between amiodarone and propafenone before and after treatment of ventricular arrhythmia and its effect on relapse. Methods: Q-Tcd was measured in two groups before and after treatment for 2 weeks. Results: ① Q-Tc was significantly prolonged after amiodarone administration, but Q-Tcd decreased (44.3 ± 14.9) mg and (33.9 ± 16.1) ms, (P <0.05) Q-Tcd no significant change (P> 0.05). ② The effective rates of amiodarone group and propafenone group were 85.2% and 82.4% respectively (P> 0.05), and the recurrence rates of ventricular arrhythmia within 1 month after discontinuation were 18.5% and 50% respectively (P> 0.05 ) Q-Tcd in propafenone group was significantly longer (48.7 ± 15.3) ms and (39.8 ± 12.5) ms than recurrence group (P <0.01). Conclusions: The reduction of Q-Tcd may be an important factor in the low relapse rate of amiodarone in the treatment of ventricular arrhythmia.