论文部分内容阅读
缺氧诱导因子-1α(HIF-1α)与多种肿瘤的耐药均密切相关〔1-2〕,该研究前期显示卵巢癌顺铂耐药细胞株SKOV-3/DDP转染HIF-1αsiRNA表达载体后,对顺铂(DDP)的耐药性明显缓解。该实验进一步验证了沉默HIF-1α基因在动物模型体内逆转耐药性的效果和机制。该实验中分别培养卵巢癌细
The hypoxia-inducible factor-1α (HIF-1α) is closely related to the resistance of various tumors (1-2). In the early stage of the study, the expression of HIF-1αsiRNA in SKOV-3 / DDP ovarian cancer cells After the carrier, resistance to cisplatin (DDP) was significantly relieved. This experiment further validates the effect and mechanism of silencing HIF-1α gene in reversing drug resistance in animal models. The experiments were cultured ovarian cancer fine