含有亚氨基二乙酸取代基的酚类化合物常用于二价金属钴、镍、锰的配位滴定以及碱土金属的鳌合剂,工业上用作水的软化剂.我们在寻找放射性核素加速排除药物时,以带有不同取代基团的苯酚、苯二酚与亚氨基二乙酸、甲醛进行 Mannich 反应,合成了十八个含有亚甲氨基二乙酸基取代的酚类衍生物.其中1a~([3]),1b~([1]),1c~([4]),2c~([3]),3a~([4]),3c~([5])及4a~([4])为已知化合物. Phenolic compounds containing iminodiacetic acid substituents are commonly used in the coordination titration of divalent metallic cobalt, nickel, and manganese, as well as chelating agents for alkaline earth metals, and are used industrially as softeners for water. We are looking for radionuclide accelerating drugs , The mannich reaction of phenol, hydroquinone with iminodiacetic acid and formaldehyde with different substituents was carried out to synthesize eighteen phenolic derivatives containing methylenediacet diacetoxyl substituted 1a ~ ([ 4], 2c ~ ([3]), 3a ~ ([4]), 3b ~ ([5]) and 4a ~ ([4] ) Is a known compound.