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目的研究炮制前、后亳州丹皮水提物对大鼠心肌缺血再灌注损伤血流动力学的影响。方法结扎大鼠左冠状动脉前降支30 min,再灌注60 min的方法复制大鼠心肌缺血再灌注损伤模型。将大鼠随机分为假手术组、模型组、炮制前丹皮组、炮制后丹皮组。多时间点测定各组大鼠血流动力学指标的平均动脉压(MBP)、左心室收缩压(LVSP)、左心室舒张末期压(LVEDP)、左心室等容期压力最大上升速率(+dp/dt max)、左心室等容期压力最大降低速率(-dp/dt max)、心率(HR)及其心电图ST段的变化。结果与模型组相比,炮制前、后丹皮组大鼠的MBP、LVSP、±dp/dt max、HR均高于模型组,LVEDP均低于模型组,并能有效降低心电图ST段抬高的程度。结论炮制前、后的丹皮水提物对心肌缺血再灌注损伤大鼠的心电图有一定的改善作用,且能明显改善心功能,但炮制前、后丹皮之间差异无统计学意义,说明已炮制的丹皮虽然外观较好,但是药效并未见增强。
Objective To study the effects of aqueous extract of Danzhou bark before and after processing on the hemodynamics of myocardial ischemia-reperfusion injury in rats. Methods Rats with left anterior descending coronary artery were ligated for 30 min and then reperfused for 60 min to establish a model of myocardial ischemia reperfusion injury in rats. The rats were randomly divided into sham operation group, model group, concocted Dan Dan skin group and processed Dan Dan skin group. The mean arterial blood pressure (MBP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular maximal pressure rise during the isovoltong phase (+ dp / dt max, -dp / dt max, heart rate (HR) and ST segment of electrocardiogram in left ventricular. Results Compared with the model group, the MBP, LVSP, ± dp / dt max and HR of the rats in the DanPi group before and after processing were significantly higher than those in the untreated group and LVEDP was lower than those in the model group, and the ST segment elevation Degree. Conclusions The water extract of Dandelion before and after processing can improve the electrocardiogram of myocardial ischemia-reperfusion injury in rats, and can significantly improve the cardiac function, but there is no significant difference between before and after processing of Dan- Description has been concocted Paeonia although appearance is better, but the efficacy has not seen enhanced.