患者,女,86岁,有食管炎病史10a(年),间断用过西咪替丁或雷尼替丁.1989年因症状进行性加重,开始服用奥美拉唑40mg,pd,此时血清肌酐浓度正常.两月后因肾衰住院,血清肌酐高达858umol/L.肾活检证实为间质性炎症,可见浆细胞、淋巴细胞、嗜酸细胞以及斑块样肾小管炎症改变.但肾小球未受累及.具有急性间质性肾炎的特征.患者住院前两周因疑有肺炎而接受红霉素治疗.两药均停用,予利尿剂治疗,肾功能恢复正常.当时曾怀疑为红霉素的副作用. Patients, female, 86 years old, had a history of esophagitis 10a (years), discontinued cimetidine or ranitidine .1989 due to progressive aggravation of symptoms, began taking omeprazole 40mg, pd, serum Creatinine normal two months later hospitalized for renal failure, serum creatinine as high as 858umol / L. Renal biopsy confirmed interstitial inflammation, showing changes in plasma cells, lymphocytes, eosinophils and plaque-like tubular inflammation, but small The ball is not involved. Has the characteristics of acute interstitial nephritis. Patients admitted to hospital two weeks before due to suspected pneumonia and receive erythromycin. Both drugs were discontinued, diuretics, renal function returned to normal. Was suspected Side effects of erythromycin.