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目的为了解六安市21-三体综合征(唐氏综合征)、18-三体综合征(爱德华氏综合征)及NTD(神经管畸形)的发病率,旨在促进六安市产前筛查工作的更好开展。方法采用时间分辨荧光免疫分析法(DELFIA)对全市2008年1月至2012年4月在我院产前门诊8020例孕妇进行产前筛查。结果 8020例孕妇中21-三体综合征高风险213例,高风险率1/38、18-三体综合征高风险43例,高风险率1/187;NTD高风险64例,高风险率1/125,确诊NTD1例。结论结果表明六安市对产前筛查预防工作有成效,进一步开展产前筛查工作;扩大筛查覆盖率,对实施出生缺陷干预工程,提高出生人口素质有重大意义。
Objective To understand the incidence of 21-trisomy syndrome (Down’s syndrome), 18-trisomy syndrome (Edwards syndrome) and NTD (neural tube deformity) in Lu’an City in order to promote prenatal Screening work better. Methods The time-resolved fluorescence immunoassay (DELFIA) was used to screen 8020 pregnant women in prenatal clinics of our hospital from January 2008 to April 2012. Results Among 8020 pregnant women, there were 213 cases with high risk of trisomy 21, 43 cases with high risk 1 / 38,18-trisomy syndrome with high risk of 1/187, 64 cases with high risk of NTD, high risk 1/125, diagnosed NTD1 cases. Conclusion The results show that the prevention and treatment of prenatal screening in Lu’an City is effective and the prenatal screening work is further carried out. Enlarging the screening coverage rate is of great significance to the implementation of birth defects intervention project and improvement of the quality of the born population.