既往的随机对照研究结果显示,小剂量阿司匹林能有效降低男性的首发心肌梗死和缺血性卒中风险。然而关于其对女性心血管疾病的一级预防作用尚不清楚,本文就此进行了分析。受试对象为39 876例女性,年龄均≥45岁,皆来自妇女健康研究(WHS)。先前均无心脑血管病、肿瘤或其它慢性疾病史,亦从未服用非类固醇性抗炎药(NSAIDs)、抗凝药或激素类 Previous randomized controlled studies have shown that low-dose aspirin can effectively reduce the risk of first-mover and ischemic stroke in men. However, its primary preventive effect on cardiovascular disease in women is not yet clear, and the article analyzes this issue. Subjects were 39 876 women aged ≥45 years, all from the Women’s Health Study (WHS). There was no previous history of cardiovascular and cerebrovascular diseases, cancer or other chronic diseases and never taking non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants or hormones