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自铂类化合物问世以来,提高了很多恶性肿瘤化学治疗疗效.但顺铂(PDD)的肾毒性和胃肠道反应以及卡铂的骨髓抑制作用限制了它们的广泛应用.用1.2-二氨基环己烷取代PDD的氨基,其他带有阴离子残基的基团取代氯离子,合成出第3代铂类化合物奥沙利铂(OxaliPlatin,L-OHP,化学名为左旋反式二氨环己烷草酸铂,国际通用名为草酸铂)的问世,无疑给临床医生提供了一种新的有前途的化疗药物.在法国开展的临床前期和Ⅰ期临床试验及在多国家进行的Ⅱ、Ⅲ期临床试验表明,L-OHP无论单药还是联合用药,治疗大肠癌和进展期卵巢癌均表现出有效率高、安全、广谱,骨髓抑制轻微,胃肠道反应较少而且易于控制,无明显的肾、耳毒性.但可致末梢神经炎,表现为肢体末端感觉障碍和麻木是其缺陷,现就其不良
Since the advent of platinum-based compounds, the efficacy of many chemotherapeutic agents for malignant tumors has been enhanced, but nephrotoxicity and gastrointestinal reactions of cisplatin (PDD) and the myelosuppression of carboplatin have limited their widespread use.1,2-Diaminocyclo Hexane to replace the amino group of PDD, other groups with anionic residues replaced by chloride ions, the third generation of platinum compounds oxaliplatin (L-OHP, chemical name is levorotatory transcyclohexane Oxaliplatin, commonly known international name for the oxaliplatin) will undoubtedly provide clinicians with a new promising chemotherapeutic drugs in France carried out in preclinical and phase Ⅰ clinical trials and in many countries Ⅱ, Ⅲ Clinical trials show that both L-OHP treatment of colorectal cancer and advanced ovarian cancer have shown high efficiency, safety, broad spectrum, minimal myelosuppression, less gastrointestinal reaction and easy to control, no matter single or combination Of the kidney, ototoxicity, but can be caused by peripheral neuritis, manifested as limb extremity sensory disturbances and numbness is its defect, is now on its bad