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目的观察尼可地尔治疗射血分数正常的心力衰竭的临床疗效。方法对信阳市中心医院心血管内科收治的因高血压引起的射血分数正常的心力衰竭患者共100例随机进行分组,分为观察组和对照组,各50例。对照组给予常规治疗,观察组在常规治疗基础上加用口服尼可地尔治疗。比较两组患者临床治疗效果、治疗前后超声心电图参数:室间隔厚度(IVST)、左室后壁厚度(LVPWT)、二尖瓣舒张早期流速峰值(E)、二尖瓣舒张晚期流速峰值(A)、二尖瓣环舒张早期流速峰值(e)、E/A、E/e、及6min步行试验距离(6MWY)、N末端脑钠肽前体(NT-proBNP)。结果两组患者治疗结果显示,观察组的总有效率为96.0%显著高于对照组84.0%(P<0.05),治疗后患者的E,e、E/A及6MWY均升高,IVST,LVPWT,A,E/e,NT-proBNP均降低,差异均具有统计学意义(P<0.05)。并且观察组的参数升高及降低幅度均明显高于对照组。结论在常规治疗的基础上加用口服尼可地尔治疗射血分数正常的心力衰竭,能有效改善患者临床症状及舒张功能指标,提高患者心脏舒张功能。
Objective To observe the clinical efficacy of nicorandil in the treatment of heart failure with normal ejection fraction. Methods A total of 100 patients with heart failure due to hypertension who were admitted to Department of Cardiology, Xinyang Central Hospital were randomly divided into observation group and control group, with 50 cases in each group. The control group was given routine treatment, and the observation group was treated with oral nicorandil on the basis of routine treatment. The echocardiographic parameters including IVST, LVPWT, early diastolic mitral flow velocity (E) and mitral early diastolic velocity flow velocity (A) were compared between the two groups before and after treatment. ), Peak early diastolic velocity of mitral annulus (e), E / A, E / e, 6MWY and NT-proBNP. Results The results of two groups of patients showed that the total effective rate was 96.0% in the observation group and 84.0% in the control group (P <0.05). After treatment, the E, e, E / A, , A, E / e, NT-proBNP were decreased, the differences were statistically significant (P <0.05). And the parameters of the observation group increased and decreased significantly higher than the control group. Conclusion The addition of oral nicorandil to patients with normal ejection fraction on the basis of routine treatment can effectively improve the clinical symptoms and diastolic function indexes and improve the diastolic function in patients.