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目的通过研究左、右半结肠癌的临床及病理特征,探索其临床及生物学特性的区别,为后续开展的分子机制研究奠定基础。方法收集2001年1月至2010年12月在结直肠肿瘤外科,1810例经手术治疗结肠癌患者的临床及病理资料。其中男性984例,女性826例,平均年龄为59.7±11.9岁。右半结肠癌921例,占50.9%。应用卡方检验,对比分析左、右半结肠癌临床表型的区别。结果左、右半结肠癌在年龄(χ2=11.4792,P<0.01)、性别(χ2=6.8361,P<0.01)、大体型态(χ2=4.7157,P<0.05)、T分期(P<0.01)、病理类型(χ2=40.9880,P<0.01)、病理分化(χ2=25.4816,P<0.01)、淋巴结切除数(χ2=85.5153,P<0.01)中存在显著统计学差异。其中右半结肠癌患者中年龄组小于50岁和大于69岁发病率高;女性较男性多发;病理分期较晚的患者中粘液腺癌和印戒细胞癌多见。结论左、右半结肠癌在临床及生物学特性间存在差异,表明左、右半结肠癌可能为不同性质的肿瘤,存在不同的致癌机制。
Objective To investigate the clinical and pathological features of left and right colon cancer and to explore the differences between the clinical and biological characteristics so as to lay the foundation for the subsequent study of molecular mechanism. Methods The clinical and pathological data of 1810 colon cancer patients who underwent surgery in colorectal cancer surgery from January 2001 to December 2010 were collected. There were 984 males and 826 females, with an average age of 59.7 ± 11.9 years. Right colon cancer 921 cases, accounting for 50.9%. Using chi-square test, comparative analysis of the left and right colon cancer clinical phenotype differences. Results The left and right colon cancer showed significant differences in age (χ2 = 11.4792, P <0.01), gender (χ2 = 6.8361, P <0.01) , Pathological type (χ2 = 40.9880, P <0.01), pathological differentiation (χ2 = 25.4816, P <0.01) and lymph node resection count (χ2 = 85.5153, P <0.01). Including right colon cancer patients in the age group less than 50 years of age and greater than 69 years of age; women more frequently than men; mucosal adenocarcinoma and signet ring cell carcinoma more common in patients with pathological stage. Conclusion There is a difference between the clinical and biological characteristics of left and right colon cancer, indicating that left and right colon cancer may be different types of tumors, there are different oncogenic mechanisms.