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将63例格列奎酮与优降糖治疗的20例早期DN比较2组治疗12周前后的UAE、CRP、TNK-α、IL-6、TG的变化。结果格列奎酮组UAE 136±32μg/min,CRP 6.4±1.8mg/L、TNK-α 5.34±1.67pg/ml、IL-6 6.45±2.12pg/ml、TG2.63±0.68mmol/L,较治疗前有明显下降,与优降糖组相比有明显差异(P<0.01)。结论格列奎酮治疗DN的机理可能与降低患者血清中的CRP等有关
The changes of UAE, CRP, TNK-α, IL-6 and TG in 20 cases of early DN treated with gliquidone and glyburide were compared between the two groups before and after treatment for 12 weeks. Results The levels of UAE 136 ± 32μg / min, CRP 6.4 ± 1.8mg / L, TNK-α 5.34 ± 1.67pg / ml, IL-6 6.45 ± 2.12pg / ml and TG 2.63 ± 0.68mmol / Compared with before treatment, there was a significant decrease (P <0.01). Conclusion The mechanism of Gliquidone in treating DN may be related to the reduction of CRP in patients’ serum