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目的 研究 2型糖尿病视网膜病变病人的胰岛分泌情况。方法 应用葡萄糖 胰岛素释放实验对2型糖尿病病人 98例 (其中 6 6例视网膜病变病人 ,无视网膜病变组病人 32例 )、正常对照组 32例进行血糖、胰岛素测定 ,计算血糖及胰岛素曲线面积、胰岛素敏感性指数、胰岛素分泌指数并进行比较。结果 糖尿病两组各时相血糖值及血糖面积均非常显著高于正常对照组 ;糖尿病有视网膜病变组各时相血糖值及血糖面积均显著高于无视网膜病变组 (P <0 0 1) ;糖尿病有视网膜病变组各时相胰岛素值及胰岛素面积均显著低于无视网膜病变组 (P <0 0 1) ;糖尿病有视网膜病变组的胰岛素分泌指数显著低于无视网膜病变组 (P <0 0 1)。多元逐步回归分析表明 ,视网膜病变与病程呈正相关 ,与胰岛素分泌指数负相关 (P <0 0 1)。结论 2型糖尿病视网膜病变的病人存在着严重的持续高血糖 ,胰岛素分泌障碍是 2型糖尿病视网膜病变的危险因素。
Objective To study the pancreatic islet secretion in patients with type 2 diabetic retinopathy. Methods Glucose and insulin release test was used in 98 patients with type 2 diabetes mellitus (including 66 cases of retinopathy and 32 cases without retinopathy) and 32 cases of normal control group. Blood glucose and insulin were measured and the area of blood glucose and insulin curve were calculated. Insulin Sensitivity index, insulin secretion index and compared. Results The blood glucose and blood glucose of each phase in diabetic group were significantly higher than those in normal control group. The blood glucose and blood glucose of diabetic patients with retinopathy were significantly higher than those without retinopathy (P <0.01). The insulin value and insulin area in diabetic retinopathy group were significantly lower than those in non-retinopathy group (P <0.01). The insulin secretion index in diabetic retinopathy group was significantly lower than that in non-retinopathy group (P <0 0) 1). Multiple stepwise regression analysis showed that retinopathy was positively correlated with the course of disease and negatively correlated with insulin secretion index (P <0.01). Conclusion Patients with type 2 diabetic retinopathy have severe persistent hyperglycemia and insulin secretion disorder is a risk factor for type 2 diabetic retinopathy.