论文部分内容阅读
在整个雌性生殖活动中,雌激素和孕激素起着重要作用,尤其对子宫机能的调控更是必不可少。在生理状态下,雌激素和孕激素与其它甾体激素一样,很容易透入靶细胞膜,然后与细胞浆内特异的可溶性受体蛋白以非共价键形式结合,形成较稳定的激素-受体复合物。经变构后进入细胞核启动相应的DNA,产生其特定的生物效应。因此,激素对靶细胞作用的强弱除取决于血中激素的浓度外,还取决于激素受体的特异性、亲和力及其含量,并与激素受体复合物在细胞核内存留的时间以及受体蛋白消耗和合成的速度有关。故研究激素受体在靶细胞内的含量和变化规律较单纯测定血液中激素的含量更能反映该激素的生物学作用。本文拟就雌激素和孕激素受体在子宫及其内膜中含量的动态变化规律进行探讨。
Throughout the female reproductive activities, estrogen and progesterone play an important role, especially on the regulation of uterine function is even more essential. Physiologically, estrogen and progestin, like other steroid hormones, readily penetrate the target cell membrane and then bind non-covalently to specific soluble receptor proteins in the cytoplasm to form more stable hormones Body complex. Transformed into the nucleus to start the corresponding DNA, resulting in its specific biological effects. Therefore, the role of hormones on target cells in addition to depending on the strength of the hormone in the blood, but also depends on the specificity of the hormone receptor, affinity and its content, and hormone receptor complex in the nucleus of the retention time and by Body protein consumption and the speed of synthesis. Therefore, the study of hormone receptor in the target cell content and changes in the law than the simple determination of blood levels of the hormone can better reflect the biological role of the hormone. This article intends to estrogen and progesterone receptors in the uterus and its intima in dynamic changes in content to explore.