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在壳聚糖溶液中加入镧离子使形成壳聚糖镧 (III)配合物 ,用H2 O2 对形成的壳聚糖La (III)配合物进行氧化降解 ,测定了降解产物的分子量分布。结果表明壳聚糖镧配合物在过氧化氢的存在下降解迅速 ,降解从大分子量范围开始 ,降解产物寡糖分子量分布窄于目前通用方法。分布指数与寡糖的平均数均分子量有关 ,分子量在 10个糖以上时 ,DP越小 ,分布指数越小。同时对壳聚糖、壳聚糖镧配合物进行了清除O2 - 自由基的对比研究 ,发现壳聚糖镧配合物清除O2 - 自由基活性高于壳聚糖自身。
The lanthanum ions were added into the chitosan solution to form lanthanum (III) complexes of chitosan, and the formed chitosan La (III) complexes were oxidatively degraded with H2O2. The molecular weight distribution of degradation products was determined. The results showed that chitosan lanthanum complexes degrade rapidly in the presence of hydrogen peroxide. The degradation starts from a large molecular weight range, and the molecular weight distribution of the degrading oligosaccharides is narrower than the current common method. The distribution index is related to the average molecular weight of oligosaccharides. When the molecular weight is above 10 sugars, the smaller the DP, the smaller the distribution index. At the same time, the chitosan and chitosan lanthanum complexes were scavenged O2 - free radicals were compared, and found that chitosan Lanthanum complex clearance O2 - free radical activity higher than the chitosan itself.