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目的 探讨硫酸镁加喘乐宁联合雾化吸入治疗小儿支气管哮喘的有效性和安全性。方法 将 30例哮喘急性发作患儿随机分为硫酸镁和喘乐宁联合吸入组、单用喘乐宁吸入组。吸入喘乐宁的剂量均为每次 2 5 0～3 75mg ,单用喘乐宁组加 2mL生理盐水 ,联合组加 2mL的 7 5 %硫酸镁溶液。观察两组治疗前后呼吸、心率、血压 ;测量治疗前以及治疗后 10min、2 0min最大呼气峰流速 (PEFR)。结果 联合组PEFR明显高于单用喘乐宁组 ,联合组PEFR增加的百分比是单用喘乐宁组的 2倍 (P <0 0 5 ) ,联合组治疗前PEFR越低治疗后PEFR上升幅度越高。硫酸镁吸入治疗后无一例患儿出现血压下降等不良反应。结论 哮喘急性发作患儿在喘乐宁吸入的基础上加用硫酸镁吸入比单用喘乐宁吸入有更好的治疗效果 ;硫酸镁吸入治疗在儿童是安全的。
Objective To investigate the efficacy and safety of magnesium sulfate plus salbutamol combined with atomizing inhalation in the treatment of pediatric bronchial asthma. Methods Thirty children with acute asthma attack were randomly divided into two groups: the combination of magnesium sulfate and salbutamol, and the inhalation of salbutamol alone. The dose of inhalation of salbutamol were 250 ~ 375mg each time, only Salvianing group plus 2mL of normal saline, combined group plus 2mL of 75% magnesium sulfate solution. The respiratory rate, heart rate and blood pressure before and after treatment were observed. The maximum expiratory flow velocity (PEFR) before treatment and after 10 min and 20 min were measured. Results The PEFR in the combination group was significantly higher than that in the asthma alone group. The PEFR percentage in the combined group was double that of the triamterene group (P <0.05), and the PEFR in the combined group was lower The higher. There was no adverse reactions such as blood pressure drop in children after inhalation of magnesium sulfate. Conclusions Children with acute asthma attack have better therapeutic effect than inhalation of asthma alone on the basis of inhalation of salbutamol. Magnesium sulfate inhalation is safe in children.