目的:评价十一酸睾酮胶丸治疗克氏综合征的临床疗效。方法:回顾性分析17例克氏综合征患者的临床资料。17例患者均以“外生殖器发育差”或“婚后不育”就诊,年龄16～35岁,睾丸容积1～12 mL,第二性征发育较差;性激素检查血睾酮值降低(79～320 ng/dL),卵泡刺激素值升高(22.36～81.30 mIU/mL),黄体生成素值升高(8.52～37.12mIU/mL);患者均经外周血染色体检查确诊(16例核型为47XXY,1例为46XY/47XXY)。17例患者均予以十一酸睾酮胶丸行激素替代治疗(120～160 mg/d,分2次饭后立即服用,复查血睾酮水平正常后以低剂量维持治疗),并随访其治疗效果。结果:17例患者均获随访,其第二性征、性欲和勃起功能得到不同程度的改善,未发现与十一酸睾酮胶丸行激素替代治疗有关的不良反应。结论:十一酸睾酮胶丸替代治疗克氏综合征安全、方便、有效,能提高患者生活质量。 Objective: To evaluate the clinical efficacy of testosterone undecanoate in the treatment of Klinefelter’s syndrome. Methods: The clinical data of 17 Kirschner’s syndrome patients were retrospectively analyzed. Seventeen patients were treated with “poor external genitalia” or “post-natal infertility”, aged 16-35 years. The testicular volume was 1 to 12 mL and the secondary sexual characteristics were poorly developed. Sex hormone test showed that blood testosterone level (79- 320 ng / dL), elevated follicle stimulating hormone (22.36-81.30 mIU / mL), and elevated luteinizing hormone (8.52- 37.12 mIU / mL). All patients were diagnosed by peripheral blood chromosomal examination (16 Case karyotype was 47XXY, 1 case was 46XY / 47XXY). All the 17 patients were treated with hormone replacement therapy (120 ~ 160 mg / d), taking testosterone undecanoate capsules immediately after 2 meals, keeping the blood testosterone level at a low dose after the normal test, and the follow-up treatment was performed. RESULTS: All the 17 patients were followed up. The second sexual characteristics, sexual desire and erectile function were improved to some extent. No adverse reactions were found to be associated with hormone replacement therapy with testosterone undecanoate. Conclusion: Testosterone undecanoate capsules for the treatment of Klinefelter syndrome is safe, convenient and effective, can improve the quality of life of patients.