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用不同浓度的柠檬酸铝、混合稀土或硒酸钠溶液浸泡温石棉１ 小时后，再将其与人胚肺（ＨＥＬ） 细胞共同孵育，测定培养液中超氧阴离子（Ｏ－２ ） 含量。结果显示，温石棉可诱导ＨＥＬ细胞产生Ｏ－２ 。但与未处理温石棉组相比，经３ 种化合物预处理的温石棉所致ＨＥＬ细胞产生的Ｏ－２ 量明显降低，其抑制率随化合物浓度的增加而增高，呈一定的剂量依赖性。表明用上述３ 种化合物预处理温石棉，均可抑制其诱导ＨＥＬ细胞产生Ｏ－２ 。
After soaking chrysotile asbestos with different concentrations of aluminum citrate, mixed rare earth or sodium selenate solution for 1 hour, the cells were incubated with human embryonic lung (HEL) cells to determine the content of superoxide anion (O-2). The results show that chrysotile can induce HEL cells produce O-2. However, compared with the untreated chrysotile group, the amount of O-2 produced by HEL cells pretreated with three compounds was significantly decreased, and the inhibition rate increased with the concentration of the compound, in a dose-dependent manner. These results indicate that pretreatment of chrysotile with these three compounds inhibited the induction of O-2 by HEL cells.