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目的：探讨肾康注射液联合前列地尔和对慢性肾衰竭（ CRF）治疗效果及对脂代谢紊乱的影响。方法选取2012年3月至2014年2月湖北医药学院附属东风医院收治的CRF患者87例，采用随机数字表法分为对照组（43例）和观察组（44例）。对照组予以前列地尔治疗，观察组在对照组基础上予以肾康注射液治疗，治疗4周。比较两组治疗前后血清肌酐、尿素氮以及24 h尿蛋白定量等肾功能指标，芳香酯酶、载脂蛋白A、载脂蛋白B、三酰甘油、总胆固醇以及高密度脂蛋白胆固醇的变化。结果治疗后观察组患者血清肌酐、尿素氮及24 h尿蛋白定量等肾功能指标水平显著低于对照组[（302±99） mmol／L比（355±105） mmol／L，（16±3） mmol／L比（18±3） mmol／L，（1.2±0.6） g比（1.6±0.7） g，P＜0.05或P＜0.01]，且两组均较治疗前显著降低（P＜0.05）。治疗后观察组芳香酯酶、载脂蛋白A、高密度脂蛋白胆固醇显著高于对照组[（0.241±0.014） U／L 比（0.223±0.012） U／L，（1.36±0.16） mmol／L 比（1.27±0.18） mmol／L，（1.35±0.21） g／L 比（1.23±0.22） g／L，P＜0.05或P＜0.01]，三酰甘油、总胆固醇、载脂蛋白B 显著低于对照组[（1.65±0.21） mmol／L 比（1.88± 0.27） mmol／L，（4.5±0.4） mmol／L比（4.8±0.5） mmol／L，（0.88±0.09） g／L比（0.95±0.11） g／L， P＜0.01]。观察组的治疗有效率显著高于对照组[52.4％（23／44）比30.2％（13／43），P＜0.05]。结论肾康注射液联合前列地尔治疗CRF的疗效显著，能显著改善患者肾功能，调节脂代谢紊乱。“,”Objective To investigate the efficacy of Shenkang injection combined with western medi-cine in the treatment for chronic renal failure ( CRF) and its effect on lipid metabolism disorder .Methods A total of 87 CRF patients admitted in Dongfeng Hospital Affiliated to Hubei Medical and Pharmacy College from Mar.2012 to Feb.2014 were randomly divided into the control group(43 cases) and the observation group(44 cases).Patients in the control group were treated with alprostadil,while patients in the observation group were treated with Shenkang injection therapy on the basis of the control group .The serum levels of urea nitrogen(BUN),creatinine(SCr) and 24 h urinary protein(UPro),as well as changes of aromatic esterase (ArE),apolipoprotein A,apolipoprotein B,triacylglycerol(TG),total cholesterol(TC),and high density lip-oprotein cholesterol( HDL-C ) of the two groups before and after treatment were compared .Results After treatment in the observation group,levels of BUN,SCr and 24 h UPro were significantly higher than those of the control group[(302 ±99) mmol/L vs (355 ±105) mmol/L,(16 ±3) mmol/L vs (18 ±3) mmol/L, (1.2 ±0.6) g vs (1.6 ±0.7) g,P<0.05],and such indexes of both groups were declined significantly than those before treatment(P<0.05).After treatment,levels of ArE,ApoA and HDL-C of the observation group were significantly higher than the control group[(0.241 ±0.014) U/L vs (0.223 ±0.012) U/L,(1.36 ± 0.16) mmol/L vs (1.27 ±0.18) mmol/L,(1.35 ±0.21) g/L vs (1.23 ±0.22) g/L,P<0.05].Levels of TG,TC, ApoB were significantly lower than the control group [( 1.65 ±0.21 ) mmol/L vs ( 1.88 ± 0.27) mmol/L,(4.5 ±0.4) mmol/L vs (4.8 ±0.5) mmol/L,(0.88 ±0.09) g/L vs (0.95 ±0.11) g/L, P<0.05].The effective rate of the observation group was significantly higher than the control group[52.4%(23/44)vs 30.2%(13/43),P<0.05].Conclusion The curative effect of Shenkang injection combined with alprostadil is obvious in the treatment for CRF ,it can significantly improve the renal function ,regulate the lipid metabolism disorder of the patients.