目的　评价经皮穿刺无水乙醇注射 (PAI)治疗肾上腺肿瘤的临床价值。方法　对 14例 (包括 1例开放手术后复发的恶性嗜铬细胞瘤患者 )行PAI术和 13例行开放肾上腺手术患者的临床资料进行分析 ,比较两组近期疗效、手术时间、术中平均出血量、术后住院天数、住院总费用及术后并发症。结果　随访 1年 ,1例恶性嗜铬细胞瘤患者因术后复发多次行PAI术 ,每次术后患者血压、血糖下降明显 ,降压药及降糖药剂量明显减少。其余患者血压下降 ,未见肿瘤复发。PAI组在手术时间、术中平均出血量、术后住院天数、住院总费用均优于开放手术组。PAI组主要并发症是腰痛 ,但症状很轻微。开放肾上腺手术组 1例出现休克 ,2例因感染出现高热。结论　PAI术近期疗效与开放手术组相似 ,且具有简单、安全、价廉、创伤小等优点 Objective To evaluate the clinical value of percutaneous ethanol injection (PAI) in the treatment of adrenal tumors. Methods The clinical data of 14 patients (including 1 malignant pheochromocytoma recurrence after open surgery) undergoing PAI and 13 patients undergoing open adrenalectomy were analyzed. The short-term curative effect, operative time, mean intraoperative blood loss Volume, postoperative hospital stay, total cost of hospitalization and postoperative complications. Results One year follow-up, one patient with malignant pheochromocytoma underwent PAI after multiple relapse. The blood pressure and blood glucose decreased significantly after each operation, and the dosage of antihypertensive drugs and hypoglycemic agents decreased significantly. The remaining patients with blood pressure, no tumor recurrence. PAI group in operation time, intraoperative blood loss, postoperative hospital stay, hospitalization costs were better than the open surgery group. The main complication in the PAI group is back pain, but the symptoms are mild. One patient in the adrenalectomy group had shock, and two patients developed fever due to infection. Conclusion PAI has similar curative effect in the short term as open surgery group, and has the advantages of simple, safe, inexpensive, less invasive and so on