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目的通过检测子宫内膜异位症患者(EMs)月经周期中各期血清C反应蛋白水平与正常妇女血清C反应蛋白水平对比,分析子宫内膜异位症的发病机制,以及EMs血清中C反应蛋白周期性变化规律。方法对40例EMs患者及20例正常妇女对照组应用免疫比浊法检测月经期、增生期、分泌期血清中C反应蛋白水平。结果①EMs患者CRP水平均高于正常对照组(P<0.05)②EMs患者月经期CRP水平明显高于分泌期CRP水平(P<0.05)。结论CRP水平与EMs患者的症状病情程度呈正相关,且存在周期性变化的关系。EMs患者存在一种慢性无菌性炎症状态,由于存在免疫缺陷,不能有效清除逆流腹腔的子宫内膜,促进了子宫内膜的腔外种植。
Objective To investigate the pathogenesis of endometriosis by detecting the level of serum C-reactive protein in patients with endometriosis (EMs) during the menstrual cycle and the level of serum C-reactive protein Protein cyclical changes. Methods 40 cases of EMs patients and 20 normal women control group by immunoturbidimetry menstrual phase, proliferative phase and secretory phase C-reactive protein levels. Results ① The CRP levels in patients with EMs were significantly higher than those in normal controls (P <0.05). ② The levels of CRP in menstrual phase in patients with EMs were significantly higher than those in secretory phase (P <0.05). Conclusion The level of CRP is positively correlated with the severity of symptoms and signs of EMs. EMs patients have a chronic aseptic inflammation, due to the presence of immunodeficiency, can not effectively clear the contralateral abdominal cavity of the endometrium, and promote endometrial extraluminal implantation.