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目的:探讨早期强化静脉营养对早产儿生长发育和免疫功能的影响。方法:选取2017年1月至2018年12月山西医科大学第二医院新生儿重症监护室住院治疗的早产儿150例，采用随机数字表法将患儿分为A、B和C组，每组50例，A组出生24 h内给予全静脉营养策略，B组出生48 h内给予全静脉营养策略，C组出生72 h内给予全静脉营养策略，三组均在医院观察至出院，观察三组肝功能、营养指标及免疫功能的差异。结果:A组体质量增加速度、头围增加速度和身长增加速度高于B组和C组[（22.73 ± 2.02） g/（kg·d）比（19.90 ± 1.89）和（17.60 ± 2.01） g/（kg·d）、（0.76 ± 0.17） cm/周比（0.69 ± 0.18）和（0.60 ± 0.15） cm/周、（1.21 ± 0.20） cm/周比（1.02 ± 0.24）和（0.89 ± 0.22） cm/周]，差异有统计学意义（n P0.05）。A组治疗后总白蛋白和白蛋白高于B组和C组[（49.92 ± 3.30） g/L比（45.03 ± 2.94）和（42.03 ± 3.00） g/L、（33.10 ± 2.02） g/L比（29.89 ± 1.95）和（25.59 ± 2.00）g/L]，差异有统计学意义（n P<0.05）。A组治疗后CDn 3+和CDn 4+高于B组和C组[（68.80 ± 4.01）%比（59.02 ± 3.20）%和（55.03 ± 3.10）%、（43.31 ± 2.09）%比（38.82 ± 2.06）% 和（34.40 ± 2.11）%]，而CDn 8+明显低于B组和C组[（23.30 ± 2.80）%比（28.89 ± 2.91）%、 （34.40 ± 2.05）%]，差异有统计学意义（n P<0.05）。n 结论:早期强化氨基酸营养能明显改善早产儿营养状况及免疫功能，有助于其生长发育。“,”Objective:To explore the effects of early fortified amino acid nutrition on nutritional indicators, development and immune function of premature infants.Methods:From January 2017 to December 2018, 150 premature infants hospitalized in the neonatal intensive care unit of the Second Hospital of Shanxi Medical University were selected. Using random number table method, the children were randomly divided into group A, group B and group C, with 50 cases in each group. Group A was given a total intravenous nutrition strategy within 24 h of birth, group B was given a total intravenous strategy within 48 h of birth, and group C was given a total intravenous strategy within 72 h of birth. The children in the three groups were observed in the hospital until discharged. The levels of liver function, nutritional indicators and immune function were detected in the three groups.Results:The levels of body mass increase rate, head circumference increase rate and body length increase rate in group A were higher than those in group B and group C [22.73 ± 2.02) g/(kg·d) vs. (19.90 ± 1.89) and (17.60 ± 2.01) g/(kg·d), (0.76 ± 0.17) cm/week vs. (0.69 ± 0.18) and (0.60 ± 0.15) cm/week,(1.21 ± 0.20) cm/week vs. (1.02 ± 0.24) and (0.89 ± 0.22) cm/week], and there were significant differences (n P0.05). After treatment, the levels of total albumin and albumin in group A were higher than those in group B and group C [(49.92 ± 3.30) g/L vs. (45.03 ± 2.94) and (42.03 ± 3.00) g/L, (33.10 ± 2.02) g/L vs. (29.89 ± 1.95) and (25.59 ± 2.00) g/L], and there were significant differences(n P<0.05). After treatment, the levels of CDn 3+ and CDn 4+ in group A were higher than those in group B and group C [(68.80 ± 4.01)% vs. (59.02 ± 3.20)% and (55.03 ± 3.10)%,(43.31 ± 2.09)% vs. (38.82 ± 2.06)% and (34.40 ± 2.11)%], the level of CDn 8+ in group A was lower than that in group B and group C [(23.30 ± 2.80)% vs. (28.89 ± 2.91)% and (34.40 ± 2.05)%], and there were significant differences (n P<0.05).n Conclusions:Early fortified amino acid nutrition can significantly improve the nutritional status and immune function of premature infants, and contribute to their growth and development.