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目的探讨复治肺结核患者对常用抗结核药物的耐药特点。方法对285例复治肺结核病例进行抗结核药物敏感性测定。结果对异烟肼(INH)耐药118例(41.4%),对利福平(RFP)耐药71例(24.9%),对链霉素(SM)耐药134例(47.0%),对吡嗪酰胺(PZA)耐药62例(21.8%),对乙胺丁醇(EMB)耐药87例(30.5%)。耐1种药57例(20.0%),耐2种药91例(31.9%),耐3种药81例(28.4%),耐4种药31例(10.9%),耐5种药25例(8.8%)。同时耐2～3种药物的病例明显多于耐4～5种药物者(60.3%vs.19.7%)(P<0.01)。结论复治肺结核病例容易对一线抗结核药物产生耐药性,通常需联合使用部分二线抗结核药物治疗。
Objective To investigate the drug-resistant characteristics of commonly used anti-TB drugs in patients with re-treatment of pulmonary tuberculosis. Methods 285 cases of retreatment tuberculosis cases were tested for anti-TB drug sensitivity. Results 118 cases (41.4%) were resistant to isoniazid (INH), 71 cases (24.9%) were resistant to rifampicin (RFP) and 134 cases (47.0%) were resistant to streptomycin Pyrazinamide (PZA) resistance in 62 cases (21.8%), resistance to ethambutol (EMB) in 87 cases (30.5%). The resistance to one kind of medicine was 57 cases (20.0%), the resistance to two kinds of medicine was 91 cases (31.9%), the resistance to three kinds of medicine was 81 cases (28.4%), the resistance to four kinds of medicine was 31 cases (10.9% (8.8%). At the same time, the patients who tolerated 2 ~ 3 kinds of drugs were significantly more than those who were resistant to 4 ~ 5 drugs (60.3% vs.19.7%) (P <0.01). Conclusions Patients with re-treatment of pulmonary tuberculosis are prone to develop resistance to first-line anti-TB drugs and usually need some combination of second-line anti-TB drugs.