尖锐湿疣是一种由人乳头瘤病毒感染引起的性传播疾病。人乳头瘤病毒感染、尖锐湿疣的发病及复发与机体的免疫功能密切相关。Toll样受体是天然免疫中重要的模式识别受体,通过特异性识别微生物病原体相关分子模式后,启动天然免疫并激活获得性免疫,在抗病毒的免疫应答中发挥着重要作用。该文就Toll样受体与尖锐湿疣的关系,以及Toll样受体激动剂在尖锐湿疣治疗中的研究现状作一综述。 Genital warts is a sexually transmitted disease caused by human papillomavirus infection. Human papillomavirus infection, the incidence and recurrence of genital warts and the body’s immune function are closely related. Toll-like receptors are important pattern recognition receptors in innate immunity. They play an important role in antiviral immune response through specific recognition of molecular patterns associated with microbial pathogens, initiation of innate immunity and activation of adaptive immunity. This article reviews the relationship between Toll-like receptors and condyloma acuminatum and the current status of Toll-like receptor agonists in the treatment of condyloma acuminatum.