双醋瑞因(diacerein)的活性二乙酰衍生物(rhein)是一种存在于山扁豆属植物中的具蒽醌结构的化合物,能抑制白介素1(IL1)的活性,从而降低关节软骨中胶原酶的产生。rhein剂量依赖性地抑制过氧化阴离子的形成,抑制白细胞趋化性及其吞噬作用和巨噬细胞的迁移和吞噬作用。骨关节炎患 The activity of diacerein The diacetyl derivative, a compound with an anthraquinone structure present in the genus Glyptostilon, inhibits the activity of interleukin 1 (IL1), thereby reducing collagen in articular cartilage Production of enzymes. Rhein dose-dependently inhibited the formation of peroxide anions, inhibited leukocyte chemotaxis and phagocytosis and macrophage migration and phagocytosis. Osteoarthritis