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吡喹酮治疗血吸虫病可降低病人死亡率,减少血吸虫病的传播,且会导致宿主特异免疫反应性的改变,但对后者对于宿主抗再感染能力的影响了解甚少。本文就化疗后抗血吸虫的细胞和体液应答方面进行了观察。实验:以波多黎各株曼氏血吸虫尾蚴30条皮下注射分别感染纯系雌性C57BL/6和非纯系CF_1小鼠,感染后10周或20周以吡喹酮100mg/kg,每4小时1次共3次胃内给药治疗。同时感染对照鼠不予治疗。
Praziquantel treatment of schistosomiasis can reduce the mortality of patients, reduce the spread of schistosomiasis, and lead to changes in the host-specific immune response, but little is known about the impact of the latter on host anti-retroviral ability. This article reviews the cellular and humoral responses to anti-schistosomes after chemotherapy. Experiment: 30 female C57BL / 6 and non-pure CF_1 mice were inoculated subcutaneously with 30 Schistosoma mansoni cercariae, respectively. The infected mice were treated with praziquantel 100mg / kg and once every 4 hours 10 and 20 weeks after infection 3 times intragastric treatment. Infection control mice were not treated.