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流感嗜血杆菌是引起儿童呼吸道感染的主要致病菌,它常寄居于健康人的呼吸道,属于条件性致病菌。由该菌引起的慢性感染多与其生物膜的形成密切相关,如慢性阻塞性肺疾病、肺囊性纤维化、慢性鼻-鼻窦炎、儿童分泌性中耳炎、儿童增殖体肥大等。细菌生物膜(BF)可以被形容为细菌被包埋在一层由糖分和蛋白质构成的厚厚的、黏性的屏障中。医学上估计有超过80%的人类感染性疾病由BF介导引起[1],其特殊的膜状
Haemophilus influenzae is the main cause of respiratory tract infection in children, it often lives in the respiratory tract of healthy people, are opportunistic pathogens. Chronic infections caused by the bacteria and its biofilm formation are closely related, such as chronic obstructive pulmonary disease, cystic fibrosis, chronic rhinosinusitis, otitis media in children, children with hypertrophy and so on. Bacterial biofilms (BF) can be described as bacteria that are embedded in a thick, sticky barrier of sugar and protein. Medically, more than 80% of human infectious diseases are estimated to be caused by BF [1], and their special membranous