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目的探讨静脉注射免疫球蛋白(IVIG)治疗川崎病(KD)前后血清心肌肌钙蛋白I(cTnI)浓度变化的临床意义。方法检测KD(n=42)组治疗前后及对照组(n=28)患儿血清cTnI、肌酸激酶(CK)、乳酸脱氢酶(LDH)与谷草转氨酶(GOT)的浓度。结果KD组血清cTnI浓度明显高于对照组。CK、LDH、GOT浓度与对照组比较差异无显著性意义。IVIG治疗后cTnI浓度明显低于治疗前。结论cTnI对KD患儿急性期心肌损伤有早期诊断价值;可以指导早期IVIG治疗,并可作为IVIG疗效观察指标,从而减少KD患儿心肌病变的发生。
Objective To investigate the clinical significance of serum cardiac troponin I (cTnI) concentration before and after intravenous immunoglobulin (IVIG) treatment of Kawasaki disease (KD). Methods Serum levels of cTnI, creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate aminotransferase (GOT) in children with KD (n = 42) before and after treatment and in control group (n = 28) Results Serum cTnI concentration in KD group was significantly higher than that in control group. CK, LDH, GOT concentrations compared with the control group no significant difference. After IVIG treatment cTnI concentration was significantly lower than before treatment. Conclusions cTnI is an early diagnostic value for acute myocardial injury in children with KD. It can guide early IVIG treatment and can be used as an indicator of IVIG curative effect to reduce the occurrence of myocardial lesions in children with KD.