足细胞是肾小球内高度分化和特异化的细胞,位于滤过屏障的最外层,由它发出许多长的足突并进一步分成大量二级足突,覆盖在肾小球基底膜(GBM)的外侧。在足突细胞的基底侧,足突膜通过以α3β1为主的整合素与GBM上相应的配体如板层素、Ⅳ型胶原、硫酸乙酰肝素蛋白多糖(H SPG)等结合 Podocytes are highly differentiated and specialized cells in the glomerulus, located at the outermost layer of the filtration barrier, by which it emits many long foot processes and is further divided into numerous secondary foot processes, covering the glomerular basement membrane (GBM ) Of the outside. On the basolateral side of foot processes, the foot processus integrates with α3β1-based integrins and corresponding ligands on GBM, such as laminin, type IV collagen, and heparin sulfate proteoglycan (H SPG)