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目的探讨妊娠期糖尿病患者肠道菌群及炎症因子的变化。方法选择38例在丽水市中医院就诊的妊娠期糖尿病患者为观察组,选择同期就诊的正常孕妇50例为对照组,两组患者均检测肠道双歧杆菌、乳酸杆菌、拟杆菌含量,比较菌群失调发生率,同时检测并比较炎症因子IL-2、IL-6水平,探讨两组患者的肠道菌群及炎症因子的差异。结果观察组双歧杆菌、乳酸杆菌、拟杆菌的数量均少于对照组(t_双=2.41,t_乳=2.27,t_拟=2.14,P均<0.05);观察组肠道菌群失调发生率高于对照组(χ~2=6.29,P<0.05);观察组IL-2水平较对照组低,IL-6水平较对照组高(t_(IL-2)=3.74,t_(IL-6)=3.21,P均<0.01)。结论妊娠期糖尿病患者容易出现肠道菌群失调,影响患者的免疫功能,应及早进行干预治疗。
Objective To investigate the changes of gut flora and inflammatory cytokines in gestational diabetes mellitus patients. Methods 38 cases of gestational diabetes mellitus patients treated in Lishui Hospital were selected as the observation group and 50 cases of normal pregnant women were selected as the control group. The contents of Bifidobacterium, Lactobacillus and Bacteroides were detected in both groups The incidence of flora was detected. The levels of inflammatory cytokines IL-2 and IL-6 were detected and compared at the same time. The differences of intestinal flora and inflammatory cytokines between the two groups were discussed. Results The numbers of Bifidobacterium, Lactobacillus and Bacteroidetes in the observation group were less than those in the control group (t_bis = 2.41, t_em = 2.27, t_ = 2.14, P <0.05) The incidence of the disorder was higher in the observation group than in the control group (χ ~ 2 = 6.29, P <0.05). The IL-2 level in the observation group was lower than that in the control group IL-6) = 3.21, P <0.01). Conclusions Patients with gestational diabetes are prone to intestinal flora imbalance, affecting the immune function of patients should be intervened as soon as possible.