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目的:观察消渴康颗粒联合盐酸吡咯列酮片对2型糖尿病阴虚热盛型患者糖脂代谢的影响。方法:74例2型糖尿病阴虚热盛型患者按随机数字表法分为两组,每组37例。两组均行糖尿病生活方式干预。对照组用盐酸吡咯列酮片30 mg,每日1次口服;观察组在对照组基础上加用消渴康颗粒,1剂,每日3次温服。治疗12周。两组患者均于治疗前后检测空服血糖(FBG)、糖化血红蛋白(Hb A1C)、餐后2 h血糖(2 h PG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行疗效评定。结果:临床疗效总有效率观察组为97.30%(36/37),对照组为62.16%(23/37),观察组优于对照组(P<0.05)。症状积分及FBG、2 h PG、TC、TG、HDL-C、LDL-C水平治疗前后及治疗后两组比较差异均有统计学意义(P<0.05)。结论:消渴康颗粒与盐酸吡咯列酮片合用能有效降低2型糖尿病阴虚热盛型患者血糖、血脂水平,可明显提高疗效,改善糖脂代谢。
Objective: To observe the effect of Xiaokekang granule combined with pioglitazone hydrochloride on the blood glucose and lipid metabolism in patients with type 2 diabetes. Methods: A total of 74 patients with type 2 diabetes mellitus were divided into two groups according to the random number table method, with 37 cases in each group. Both groups underwent diabetes lifestyle intervention. The control group with pyrrolizidine hydrochloride tablets 30 mg orally daily; the observation group in the control group plus Xiaokekang granules, 1, 3 times a day warm clothes. Treatment for 12 weeks. The levels of FBG, Hb A1C, 2 h PG, TC, TG, HDL-C in the two groups were measured before and after treatment. Cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and efficacy evaluation. Results: The total effective rate in the observation group was 97.30% (36/37) in the observation group and 62.16% (23/37) in the control group. The observation group was superior to the control group (P <0.05). Symptoms and FBG, 2 h PG, TC, TG, HDL-C, LDL-C levels before and after treatment and after treatment were significantly different between the two groups were statistically significant (P <0.05). Conclusion: The combination of Xiaokekang granules and pioglitazone hydrochloride tablets can effectively reduce blood glucose and blood lipid levels in patients with type 2 diabetes mellitus with yin deficiency syndrome, which can obviously improve the curative effect and improve glucose and lipid metabolism.