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为探讨肾积水患者尿内皮素（ET）与内皮行化舒张因子（EDRF）变化的关系，对40例单侧输尿管梗阻性肾积水患者ET与EDRF的水平进行检测，并与16例正常人作对照。发现在梗阻性肾积水患者肾盂尿中ET的水平较对照组明显升高（P＜0．01），EDRF的水平较对照组明显降低（P＜0．01），肾积水程度越重，上述变化越明显。提示在梗阻性肾积水中，梗阻肾合成的过量ET没有被定量的EDRF所拮抗，这可能是梗阻肾发生缺血性萎缩的一个原因。
To investigate the relationship between urinary ET and EDRF in 40 patients with hydronephrosis, the levels of ET and EDRF in 40 patients with unilateral ureteral obstruction hydronephrosis were measured and compared with 16 patients with normal Man as a control. It was found that the level of ET in renal pelvis and urine of patients with obstructive hydronephrosis was significantly higher than that of the control group (P <0.01), EDRF level was significantly lower than that of the control group (P <0.01) , The more obvious the above changes. Tip in obstructive hydronephrosis, obstructive kidney synthesis of excess ET is not quantitative EDRF antagonism, which may be obstructive renal ischemia caused by a cause.