van der Meer等研究了抗生素对天然瓣膜心内膜炎的预防作用,研究对象不包括瓣膜修复的病人。理由是这些病人极易发病。但是在研究中,瓣膜修复并患有心内膜炎的患者仅有89例,而天然瓣膜心内膜炎的病人却有349例。如果瓣膜修复的病人细菌性心内膜炎发病率很高,那么可推知任何类型的抗菌性预防作用应该更好。而且,肥大性心肌病和原先患过心内膜炎的患者,即使在没有心脏疾病时,在适于该研究的患者心脏条件中却未加以考虑,然而在最近的美国心脏 van der Meer et al studied the prophylactic effect of antibiotics on native valve endocarditis, and did not include valve repair patients. The reason is that these patients are extremely vulnerable. However, in the study, there were only 89 patients with valve repair and endocarditis, compared with 349 patients with native valve endocarditis. If the patient with valve repair has a high incidence of bacterial endocarditis, it can be deduced that any type of antimicrobial prophylaxis should be better. Moreover, hypertrophic cardiomyopathy and patients with prior endocarditis, even in the absence of heart disease, were not considered in the cardiac conditions of patients eligible for the study, but in the recent American heart