早些时侯就知道,为了得到并维持一种药物在血浆中的恒定浓度,较理想的输液方案是给予一次负荷剂量,继而实施按指数下降到能够保持稳态浓度的输注。我们最近设计了一种简单易行的方法,可获致需要的输注。药物由静脉输入后,即经血流分布进入血管外组织,而后排出体外。在输注的最初期阶段,所给药物的大部分到达血管外的隔室,面只有少量排出体外。随着时间的推 Earlier it became clear that in order to obtain and maintain a constant concentration of a drug in plasma, the more desirable infusion regimen was to administer a loading dose followed by an exponential decrease to an infusion capable of maintaining a steady state concentration. We recently designed a simple and easy way to get the needed infusion. Drugs from the vein after the blood flow distribution into the extravascular tissue, and then excreted. During the initial phase of infusion, most of the administered medication reaches the extravascular compartment with only a small amount excreted. With the push of time