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目的评价穆斯林2型糖尿病患者斋月期间口服沙格列汀的有效性及安全性。方法将85例穆斯林2型糖尿病患者随机分为2组,实验组为在斋月期间给予沙格列汀片5mg每日一次口服,对照组维持原有治疗方案,4周后收集数据,进行统计分析。结果 4周后实验组患者空腹血糖、餐后2h血糖、果糖胺、甘油三酯、胆固醇、低密度脂蛋白较对照组显著下降(P<0.05),高密度脂蛋白无明显变化(P>0.05),体重指数无明显改变(P>0.05),低血糖事件少。结论穆斯林2型糖尿病患者在斋月期间口服沙格列汀可有效控制空腹血糖、餐后血糖、果糖胺、改善脂代谢,降低低血糖风险,依从性好。
Objective To evaluate the efficacy and safety of oral saxagliptin in Muslims with type 2 diabetes during Ramadan. Methods Eighty-five Muslim patients with type 2 diabetes mellitus were randomly divided into two groups. The experimental group was given orally 5mg of Saxagliptin daily during Ramadan. The control group maintained the original treatment plan. After 4 weeks, the data were collected for statistical analysis . Results After 4 weeks, fasting blood glucose, postprandial 2h blood glucose, fructosamine, triglyceride, cholesterol, and low density lipoprotein in the experimental group decreased significantly (P <0.05) and HDL did not change significantly (P> 0.05 ), No significant change in body mass index (P> 0.05), less hypoglycemic events. Conclusions Oral administration of saxagliptin in Muslims with type 2 diabetes during Ramadan can effectively control fasting blood glucose, postprandial blood glucose, fructosamine, improve lipid metabolism, reduce the risk of hypoglycemia, and has good compliance.