石杉碱甲类似物的合成及药理研究Ⅰ.( )-14-氟石杉碱甲

来源 :化学学报 | 被引量 : 0次 | 上传用户：joyce

【摘要】

：

用两种方法合成了(±)-14-氟石杉碱甲(6),并测定了其抑制乙酸胆碱酯酶的生物活性.其抑制活性是(-)-石杉碱甲(1)的1/62. (±) -14-fluorophujine A (6) was synthesized by t

【作者】

：

曾繁星蒋华良杨玉社刘东祥陈建忠唐希灿刘静沈竞康陈凯先嵇汝运

【机构】

：

中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物研究所,中国科学院上海药物

【出处】

：

化学学报

【发表日期】

：

1999年05期

【关键词】

：

石杉碱甲氟化乙酰胆碱酯酶生物活性

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论文部分内容阅读

用两种方法合成了(±)-14-氟石杉碱甲(6),并测定了其抑制乙酸胆碱酯酶的生物活性.其抑制活性是(-)-石杉碱甲(1)的1/62. (±) -14-fluorophujine A (6) was synthesized by two methods and its inhibitory activity on the activity of acetylcholinesterase was determined. The inhibitory activity was (-) - huperzine A 1/62.

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石杉碱甲类似物的合成及药理研究Ⅰ.( )-14-氟石杉碱甲

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