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目的:观察复方丹参注射液联合盐酸拉贝洛尔片治疗早发型重度子痫前期的临床疗效。方法:选取40例早发型重度子痫前期患者,随机分为观察组和对照组各20例。观察组予复方丹参注射液合盐酸拉贝洛尔片治疗,对照组予25%硫酸镁注射液合盐酸拉贝洛尔片治疗。观察2组治疗前后平均动脉压(MAP)、24h尿蛋白定量(UP)、24h尿量(UV)、红细胞压积(HCT)、血小板计数(BPC)、D-二聚体(DD)、纤维蛋白原(Fib)及胎儿脐动脉收缩压与舒张压的比值(S/D)、羊水指数(AFI)的变化。结果:治疗后,2组MAP及UP均较治疗前降低(P<0.05),UV均较治疗前增加(P<0.05);观察组的UP低于对照组(P<0.05),UV高于对照组(P<0.05)。治疗后,2组BPC、DD、Fib水平均较治疗前降低(P<0.05),观察组BPC、DD、Fib水平比对照组下降更显著(P<0.05)。治疗后,2组S/D均减小(P<0.05),AFI均升高(P<0.05);观察组的S/D小于对照组(P<0.05),AFI高于对照组(P<0.05)。观察组活产数多于对照组,重度窒息和死产数低于对照组,差异均有统计学意义(P<0.05)。结论:复方丹参注射液联合盐酸拉贝洛尔片治疗早发型重度子痫前期,有利于改善患者的肾功能和胎盘供血,缓解血液高凝状态,降低血压,治疗效果优于硫酸镁注射液。
Objective: To observe the clinical efficacy of compound Danshen injection combined with labetalol hydrochloride in the treatment of early-onset severe preeclampsia. Methods: Forty patients with early-onset severe preeclampsia were randomly divided into observation group (20 cases) and control group (20 cases). The observation group was treated with compound Danshen injection and labetalol hydrochloride tablets and the control group with 25% magnesium sulfate injection and labetalol hydrochloride tablets. The mean arterial pressure (MAP), 24h urinary protein (UP), 24h urine output (HCT), platelet count (BPC), D-dimer (Fib) and fetal umbilical artery systolic and diastolic blood pressure ratio (S / D), amniotic fluid index (AFI) changes. Results: After treatment, the MAP and UP in both groups were significantly lower than those before treatment (P <0.05), while the levels of UV in the two groups were higher than those before treatment (P <0.05); the UP in the observation group was lower than that in the control group Control group (P <0.05). After treatment, the levels of BPC, DD and Fib in both groups were significantly lower than those before treatment (P <0.05). The levels of BPC, DD and Fib in the observation group were significantly lower than those in the control group (P <0.05). After treatment, the S / D in both groups decreased (P <0.05) and the AFI increased (P <0.05). The S / D in observation group was lower than that in control group (P < 0.05). The number of live births in the observation group was more than that of the control group, and severe asphyxia and dead birth were lower than those in the control group (P <0.05). Conclusion: Compound Salvia Miltiorrhiza injection combined with labetalol hydrochloride in early-onset severe preeclampsia can improve renal function and placental blood supply, relieve blood hypercoagulability and lower blood pressure, and its therapeutic effect is better than that of magnesium sulfate injection.