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本文作者为验证自由基参与流感发病机理的假说,首次研究了流感病毒感染的鼠肺泡吞噬细胞产生的氧自由基(O_2~-)。病毒感染8天后,在有或无佛波醇肉豆蔻酸乙酯(PMA)存在的情况下,肺泡吞噬细胞产生O_2~-的能力约为接种病毒后立即测定的8倍。除此以外,O_2~-的另一个来源是血浆和胞外间隙中的黄嘌呤氧化酶。在正常生理状态下,许多组织中这种酶的活性很低,但在缺血和再灌注后大量增加。此外,在成人呼吸窘迫综合征中,此酶活性也升高。这些结
To verify the hypothesis that free radicals are involved in the pathogenesis of influenza, the authors first studied the oxygen free radicals (O 2 -) produced by the murine alveolar macrophages infected with influenza virus. Eight days after virus infection, the ability of alveolar phagocytes to produce O 2 - in the presence or absence of phorbol myristate (PMA) was about 8-fold greater than immediately after virus challenge. In addition, another source of O2- is xanthine oxidase in the plasma and extracellular space. Under normal physiological conditions, this enzyme activity is low in many tissues, but increases significantly after ischemia and reperfusion. In addition, this enzyme activity is also elevated in adult respiratory distress syndrome. These knots