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目的回顾性分析近5 a本院收治的急性白血病(AL)患儿临床资料,探讨浓缩红细胞输注量与AL患儿骨髓完全缓解(CR)后出现骨髓幼稚细胞增生、骨髓复发的关系。方法按初次化疗CR后骨髓原始幼稚细胞分布情况将74例AL患儿分为3组:规律无事件完成化疗组(无事件组)、首次骨髓幼稚细胞增生后缓解组(增生组)与首次骨髓复发组(复发组)。应用SPSS 17.0统计软件进行单因素方差分析,并对患儿复发及增生后骨髓原始+幼稚细胞比例与患儿平均每次每公斤体质量浓缩红细胞输注量的关系行Pearson相关分析。结果 3组患儿每次每公斤体质量浓缩红细胞输注量比较,差异有统计学意义(F=4.774,P<0.05),复发组、增生组均较无事件组患儿输注浓缩红细胞明显增多,复发组亦较增生组明显增多。复发及增生后骨髓原始+幼稚细胞比例与患儿平均每次每公斤体质量浓缩红细胞输注量呈正相关(r=0.51,P<0.05)。结论浓缩红细胞输注可能是促使AL患儿出现骨髓幼稚细胞增生、骨髓复发的重要因素之一。
Objective To retrospectively analyze the clinical data of children with acute leukemia (AL) admitted to our hospital in the recent 5 years and discuss the relationship between the infused amount of concentrated red blood cells and the bone marrow hyperplasia and bone marrow recurrence after bone marrow complete remission (CR) in AL children. Methods 74 children with AL were divided into 3 groups according to the distribution of naive naive cells after primary chemotherapy: There were no events in the regular chemotherapy group (no event group), the first bone marrow hyperplasia remission group (hyperplasia group) and the first bone marrow Recurrence group (relapse group). One-way analysis of variance (ANOVA) was performed using SPSS 17.0 statistical software. The Pearson correlation analysis was used to analyze the relationship between the proportion of primary + naive cells in children with recurrent and hyperplastic bone marrow and the volume of erythrocytes per kilogram of body weight. Results The infused volume of erythrocytes per kilogram of body weight in each group was significantly different (F = 4.774, P <0.05), and the infused red blood cells in the recurrence group and the hyperplastic group were significantly higher than those in the non-incident group Increased, the recurrence group also significantly increased compared with the hyperplasia group. Recurrence and hyperplasia of bone marrow naive + naive cells with the average number of children per kilogram of body weight concentration of red blood cell transfusion volume was positively correlated (r = 0.51, P <0.05). CONCLUSION: Concentrated red blood cell infusion may be one of the important factors to promote naive cell proliferation and bone marrow recurrence in AL children.