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目的分析高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)联合液基细胞学检测(liquid-based cytology test,LCT)在宫颈癌前病变筛查中的临床价值。方法选择2010年7月至2014年7月在顺德区人口和计划生育服务中心及合作医院门诊行宫颈癌前病变筛查的1 500名妇女,对其行HR-HPV及LCT并行病理活检,分析检测结果。结果 HR-HPV检测阴性1 315例,阳性185例,阳性预测值为66.49%;LCT中无宫颈上皮内瘤变1 330例,非典型鳞状上皮88例,低度鳞状上皮内病变41例,高度鳞状上皮内病变26例,鳞状细胞癌15例,阳性预测值为64.71%;HR-HPV联合LCT检测患者的敏感性为80.34%,高于HR-HPV组(60.59%)及LCT组(51.16%)(P<0.05)。各检查方法的特异性、阳性预测值及阴性预测值比较,差异无统计学意义(P>0.05)。结论高危型HPV联合LCT检测用于筛查宫颈癌前病变具有较高的敏感性和特异性,有一定的临床参考意义。
Objective To analyze the clinical value of high-risk human papillomavirus (HR-HPV) combined with liquid-based cytology test (LCT) in the screening of cervical precancerous lesions. Methods From July 2010 to July 2014, 1 500 women who had cervical precancerous lesions screening in Population and Family Planning Service Center and Cooperative Hospital outpatient department of Shunde District were examined by HR-HPV and LCT parallel pathology. Test results. Results There were 1 315 negative and 185 positive HR-HPV tests with a positive predictive value of 66.49%. There were 1 330 cases of LCT without cervical intraepithelial neoplasia, 88 cases of atypical squamous epithelium, 41 cases of low-grade squamous intraepithelial lesion 26 cases with highly squamous intraepithelial lesion and 15 cases with squamous cell carcinoma, the positive predictive value was 64.71%. The sensitivity of HR-HPV combined LCT was 80.34%, higher than that of HR-HPV group (60.59%) and LCT Group (51.16%) (P <0.05). The specificity of each test method, positive predictive value and negative predictive value, the difference was not statistically significant (P> 0.05). Conclusion High-risk HPV combined with LCT detection for screening precancerous lesions of cervical cancer has a high sensitivity and specificity, and has certain clinical significance.