肺纤维化是一组以肺间质弥漫性渗出、浸润和纤维化为主要病变的疾病,传统认为慢性炎症起着重要作用,但基于这种认识的非特异性抗炎,免疫抑制治疗不尽人意。近年有研究提出,肺部广泛损伤后修复初期,异常失控的血管生成是纤维化性修复的触发和推动因素,早期阻断异常血管生成有可能防止肺纤维化发生。但肺纤维化中的血管调节因素及其作用机制目前研究尚浅,有待于进一步探索。 Pulmonary fibrosis is a group of diseases characterized by diffuse exudation, infiltration and fibrosis of the lung interstitium. Chronic inflammation is thought to play an important role. However, non-specific anti-inflammatory and immunosuppressive therapy based on this understanding is not enough Intentions. In recent years, studies have suggested that the initial extensive lung injury repair, abnormal control of angiogenesis is a trigger and promote fibrosis repair factors, early blocking abnormal angiogenesis may prevent pulmonary fibrosis. However, vascular regulation of pulmonary fibrosis and its mechanism of action is still shallow research needs further exploration.