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目的探讨中老年男性和绝经后女性脑梗死患者血清性激素变化。方法选取中老年男性和绝经后女性脑梗死患者为观察组(n=125),同期健康体检者为对照组(n=140)。观察组中中老年男性患者65例,其中轻型40例,中-重型25例,绝经期后女性患者60例,其中轻型35例,中-重型25例;对照组中中老年男性80例,绝经期后女性60例。采用放免法测定各组激素水平,分析中老年男性和绝经后女性脑梗死患者中激素水平的变化。结果中老年男性患者雌二醇(E2)水平和E2/T比值高于男性对照组(P<0.01),绝经后女性患者E2水平低于女性对照组(P<0.01)。男性和绝经后女性中-重型患者E2和T水平均高于轻型患者,差异有统计学意义(P<0.05)。结论中老年男性E2水平和E2/T比值升高、绝经后女性E2水平降低,可能与脑梗死的发病有关;性激素水平与脑梗死病情程度密切相关,中-重型E2和T水平较轻型明显增高。
Objective To investigate the changes of serum sex hormones in middle-aged and elderly men and postmenopausal women with cerebral infarction. Methods The middle-aged and post-menopausal female patients with cerebral infarction were selected as the observation group (n = 125), and the healthy subjects as the control group (n = 140). 65 cases of middle-aged and elderly male patients in the observation group, including 40 cases of light, 25 cases of medium-heavy, 60 cases of post-menopausal women, including 35 cases of light and medium-heavy 25 cases; 80 cases of middle-aged and elderly men in the control group, menopause 60 women after the period. The levels of hormone in each group were determined by radioimmunoassay, and the changes of hormone levels in middle-aged and post-menopausal women with cerebral infarction were analyzed. Results The estradiol (E2) level and E2 / T ratio in middle-aged and elderly men were significantly higher than those in male controls (P <0.01). The levels of E2 in postmenopausal women were lower than those in female controls (P <0.01). The levels of E2 and T in both men and postmenopausal women were significantly higher than those in the light group (P <0.05). Conclusion The E2 level and E2 / T ratio of middle-aged and elderly men are elevated, and the level of E2 is decreased in post-menopausal women, which may be related to the pathogenesis of cerebral infarction. The level of sex hormones is closely related to the severity of cerebral infarction and the levels of moderate and severe E2 and T are significantly increased .