论文部分内容阅读
目的 寻求反映肝纤维化的无创性检查。方法 联合检测 48例各种类型的肝病血清Ⅲ前胶原 (serumtypeⅢ procollagen ,PCⅢ )、透明质酸 (hyaluronateacid ,HA)、血清Ⅳ型胶原 (serumtypeⅣ procogen ,PCⅣ ) ,并与其肝组织病变对照研究。结果 显示血清HA、PCⅢ和PCⅣ水平在慢性肝炎轻度、中度、重度和重型肝炎呈现进行性升高。血清HA、PCⅢ和PCⅣ随肝组织炎症活动指数和肝组织纤维化程度加重而升高。结论 若能去除炎症因素的影响 ,可显著提高这些指标预测肝纤维化的准确性
Objective To seek noninvasive examination of liver fibrosis. Methods Serum level of Ⅲ procollagen (PC Ⅲ), hyaluronic acid (HA) and serum type Ⅳ procogen (PC Ⅳ) were detected in 48 cases of various types of liver diseases. The results showed that the levels of serum HA, PCⅢ and PCⅣ showed a progressive increase in mild, moderate, severe and severe hepatitis in chronic hepatitis. Serum HA, PCⅢ and PCⅣ increased with the increase of inflammatory activity index and hepatic fibrosis in liver tissue. Conclusion If we can remove the influence of inflammatory factors, we can significantly improve the accuracy of these indexes in predicting liver fibrosis