S100P是小型钙离子结合蛋白,属于S100家族成员,通过细胞内或细胞外功能调节细胞的各种过程,并参与各种病理过程。越来越多的研究表明,S100P在各种肿瘤细胞中异常表达,并与肿瘤细胞的生长、转移、化疗药物的耐药、新陈代谢以及不良的临床预后有关。该文主要介绍了S100P在消化道肿瘤中的功能和作用机制,及其作为新的诊断和药物治疗靶点的可能性。 S100P is a small calcium-binding protein belonging to the S100 family of members that regulates various processes of cells through intracellular or extracellular functions and is involved in various pathological processes. More and more studies have shown that S100P is abnormally expressed in various tumor cells and is related to tumor cell growth and metastasis, chemoresistance, metabolism and poor clinical prognosis. This paper mainly introduces the function and mechanism of S100P in gastrointestinal tumors and its potential as a new diagnostic and therapeutic target.