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初步研究了法莫替丁 -甲壳胺微囊的释药机理。结果表明该微囊的释药机理为几步骤相互衔接 :药物的突破效应 ,亚胺键的水解 ,甲壳胺的吸水膨胀以及药物通过胶状粘稠层向外扩散。
The drug release mechanism of famotidine-chitosan microcapsules was initially studied. The results show that the drug release mechanism of the microcapsules is a few steps that link with each other: breakthrough effects of drugs, hydrolysis of imine bonds, water swelling of chitosan, and diffusion of drugs through viscous viscous layers.