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提高金牛草药材质量标准,为评价和控制金牛草药材质量提供依据。修订金牛草的性状及显微鉴别特征,参照《中国药典》2010年版附录相关方法,对金牛草药材的水分、总灰分、酸不溶性灰分及醇溶性浸出物进行测定。以粉背蕨素A和对照药材为对照,采用薄层色谱法进行定性鉴别;制备粉背蕨素A标准品,建立金牛草指标成分粉背蕨素A的含量测定方法。建立的性状、显微、薄层鉴别方法易于操作,具有较强的专属性;样品测定结果:水分8.8%~10.9%,总灰分7.6%~11.4%,酸不溶性灰分2.5%~4.2%,醇溶性浸出物9.3%~10.2%,粉背蕨素A质量分数0.56%~0.71%。通过完善金牛草的药材质量标准,能够更有效地评价其内在质量,保证用药品质。
Improve the quality standards of Jinniucao herbs, and provide the basis for evaluating and controlling the quality of the Jinniucao herbs. Revised the characteristics and microscopic identification of the properties of Jinniucao, and determined the water, total ash, acid-insoluble ash and alcohol-soluble extracts of Jinniucao medicinal materials with reference to the relevant methods in the appendix of the 2010 edition of Chinese Pharmacopoeia. The powder metallurgy A and control herbs as a control, the use of thin layer chromatography for qualitative identification; powder metallothionein standard A preparation, the establishment of the index components of calf Dorsal ferritin A determination. The results of the sample determination showed that the moisture content was 8.8% -10.9%, the total ash content was 7.6% ~ 11.4%, the acid-insoluble ash content was 2.5% ~ 4.2%, the alcohol Soluble extract 9.3% ~ 10.2%, ferulin A powder mass fraction 0.56% ~ 0.71%. By improving the quality standards of Jinniucao herbs, it is possible to evaluate its intrinsic quality more effectively and ensure the quality of the medicinal materials.