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本文报告二个家系Q—T间期延长综合征的发病情况,并对四个病例进行运动、心得安、西地兰及压迫眼球试验,探讨其病因、发病机理和治疗作用。根据二个家系发病的特点,结合文献资料,作者提出本征为多种病因引起,除一般认为是遗传性疾病外,慢性病毒感染可能是一种重要病因。关于发病机理,临床试验结果支持交感肾上腺素能刺激作用异常的观点,本文四例以左侧心交感神经张力增高为主。本文重点讨论β—阻滞剂治疗Q—T间期延长综合征的主要作用机理,并提出洋地黄制剂及刺激迷走神经对控制昏厥发作可能是有希望的治疗方法。
This article reports the incidence of Q-T prolongation syndrome in two pedigrees. Four patients were tested for exercise, propranolol, cedilanid and ophthalmic opacities, and their etiology, pathogenesis and therapeutic effects were discussed. According to the characteristics of the incidence of the two families, combined with the literature, the author raised the intrinsic cause of a variety of causes, in addition to the general is considered to be genetic disease, chronic viral infection may be an important cause. On the pathogenesis, clinical trial results support sympathetic adrenergic stimulation abnormalities point of view, four cases of this article to the left heart sympathetic tone-based. This article focuses on the main mechanism of action of β-blocker in the treatment of Q-T prolongation syndrome and proposes that digitalis preparations and stimulation of the vagus nerve may be a promising treatment for the control of syncope.