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目的 :探讨百岁方颗粒剂对脑梗死患者认知功能障碍的干预作用。方法 :选择脑梗死患者 16 0例 ,随机分为治疗组80例 ,对照组 80例 ,分别服用百岁方及尼莫地平 ,疗程为 2个月。观察治疗前后患者的简易智力状态检查表 (MMSE)、中医症状、神经功能缺损中国中风量表 (CSS)的积分改变及血液流变学、纤维蛋白原等各项指标。结果 :临床观察表明 ,百岁方能提高脑梗死患者MMSE积分 ,降低中医症状积分 ,降低CSS积分 ,改善血液流变学。两组中医症状疗效比较 ,治疗组总有效率为 76 .2 5 % ,对照组总有效率为 5 8.75 % ,治疗组明显优于对照组 (P <0 .0 5 ) ;治疗组的中医症状积分、CSS积分、血黏度高切均优于对照组 (P <0 .0 1)。结论 :百岁方颗粒剂是改善脑梗死患者认知功能的有效中药制剂
Objective: To investigate the intervention effect of Bai Suifang Granule on cognitive dysfunction in patients with cerebral infarction. Methods: One hundred and sixty patients with cerebral infarction were randomly divided into treatment group (n = 80) and control group (n = 80). The treatment course was two months. Before and after treatment, patients’ mental status checklist (MMSE), symptom of Chinese medicine, neurological deficit score of Chinese stroke (CSS) and changes of hemorrheology, fibrinogen and other indicators were observed. Results: The clinical observation shows that the centenarian can improve MMSE score of patients with cerebral infarction, reduce TCM symptom score, reduce CSS score, and improve hemorrheology. The curative effect of TCM symptoms between the two groups was 76.25% in the treatment group and 5. 8.75% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The TCM symptoms Points, CSS scores, high blood viscosity were better than the control group (P <0.01). Conclusion: Baisaifang Granule is an effective traditional Chinese medicine preparation for improving cognitive function in patients with cerebral infarction