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人巨细胞病毒是宫内感染导致胎儿畸形、死胎的病原体,也是免疫缺陷患者感染致死及器官移植术失败的重要原因。目前治疗巨细胞病毒感染仍缺乏有效药物,虽已见从植物或微生物代谢产物中提取抗人巨细胞病毒药物的资料报道,但其抗病毒机制及其研究方法尚待完善。本文就抗人巨细胞病毒药物作用机制的研究策略作简略综述。
Human cytomegalovirus is the intrauterine infection leading to fetal malformations, stillbirth pathogens, but also immunocompromised patients died of infection and organ transplantation an important reason for the failure. At present, the treatment of cytomegalovirus infection is still lack of effective drugs. Although anti-human cytomegalovirus drugs have been reported from plant or microbial metabolites, their antiviral mechanism and research methods have not yet been improved. This article briefly reviews the research strategy of anti-human cytomegalovirus drug action mechanism.