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目的评价分析门冬氨酸鸟氨酸治疗肝性脑病的临床应用效果。方法选择2008年6月-2012年6月我院消化科收治的肝性脑病患者62例,随机分成对照组20例和治疗组42例,对照组给予常规治疗措施,治疗组在常规治疗的基础上采用门冬氨酸鸟氨酸治疗,观察比较两组患者临床有效率、神志清醒时间及血氨的变化。结果治疗组临床有效率高于对照组,神志清醒时间短于对照组,治疗后血氨低于对照组,组间差异均有统计学意义(P<0.05)。结论治疗肝性脑病应用门冬氨酸鸟氨酸能够有效降低血氨浓度、尽早恢复患者的神志,安全可靠,治疗效果显著,是目前治疗肝性脑病最佳的选择。
Objective To evaluate the clinical effect of aspartate ornithine on hepatic encephalopathy. Methods Sixty-two patients with hepatic encephalopathy admitted to Department of Gastroenterology from June 2008 to June 2012 were randomly divided into control group (n = 20) and treatment group (n = 42). The control group was given conventional treatment. The treatment group was treated on the basis of routine treatment Aspartate ornithine on the treatment, observation and comparison of clinical efficacy of the two groups, conscious time and blood ammonia changes. Results The clinical effective rate of the treatment group was higher than that of the control group, and the conscious time was shorter than that of the control group. After treatment, the blood ammonia level was lower than that of the control group. There was significant difference between the two groups (P <0.05). Conclusion Aspartic acid ornithine can effectively reduce blood ammonia concentration in treatment of hepatic encephalopathy and restore the consciousness of patients as soon as possible. It is safe and reliable and has a significant therapeutic effect. It is the best choice for the treatment of hepatic encephalopathy.