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研究了庆大霉素低产菌株胞壁合成的控制对庆大霉素生物合成的影响。研究发现，发酵过程中外源添加青霉素能有效提高庆大霉素产量。发酵６０ｈ时，添加２０ｕ／ｍｌ的青霉素１次能使摇瓶发酵效价提高１．１７倍；罐发酵效价提高０．６２倍。采用多次青霉素添加工艺能使发酵效价提高０．７８倍
The effects of control of cell wall synthesis on the gentamicin low producing strain on the biosynthesis of gentamicin were studied. The study found that exogenous addition of penicillin in the fermentation process can effectively increase the yield of gentamicin. Fermentation 60h, add 20u / ml of penicillin once can shake flask fermentation titers increased by 1.17 times; tank fermentation titers increased by 0.62 times. The use of multiple penicillin fermentation process can increase the fermentation titers 0.78 times